HORDB

ID: hor000634
Uniprot ID: Q9VC44
Protein name: Drostatin-4
Gene name: AstA
Organism: Drosophila melanogaster (Fruit fly)
Family: Allatostatin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: melanogaster subgroup, melanogaster group, Sophophora (subgenus), Drosophila (genus), Drosophilini (tribe), Drosophilinae (subfamily), Drosophilidae (family), Ephydroidea (superfamily), Acalyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0071855 neuropeptide receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0045968 negative regulation of juvenile hormone biosynthetic process
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: TTRPQPFNFGL
Length: 11(138-148)
Propeptide: MNSLHAHLLLLAVCCVGYIASSPVIGQDQRSGDSDADVLLAADEMADNGGDNIDKRVERYAFGLGRRAYMYTNGGPGMKRLPVYNFGLGKRSRPYSFGLGKRSDYDYDQDNEIDYRVPPANYLAAERAVRPGRQNKRTTRPQPFNFGLGRR
Signal peptide: MNSLHAHLLLLAVCCVGYIAS
Modification: T11 Leucine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000634_AF2.pdb

hor000634_ESM.pdb

Mass:	145598	Formula:	C59H88N16O16
Absent amino acids:	ACDEHIKMSVWY	Common amino acids:	FPT
pI:	10.55	Basic residues:	1
Polar residues:	4	Hydrophobic residues:	3
Hydrophobicity:	-64.55	Boman Index:	-2042
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	35.45
Instability Index:	6546.36	Extinction Coefficient cystines:	0
Absorbance 280nm:	0